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Synthesis and separation of 3-O-Methyl-2- and 6-[18F]-fluorodopa

✍ Scribed by Michael J. Adam; Salma Jivan

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 251 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310106

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✦ Synopsis

Abstract

3‐O‐Methyl‐2‐ and 6‐[^18^F]‐fluorodopa were synthesized in 8% radiochemical yield by the direct fluorination of a protected L‐dopa derivative with [^18^F]‐acetyl hypofluorite. The 2‐ and 6‐fluoro isomers were separated and purified by reverse phase HPLC.

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