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Synthesis and purification of l-6-[18F]fluorodopa

✍ Scribed by M.J. Adam; S. Jivan

Publisher
Elsevier Science
Year
1988
Weight
308 KB
Volume
39
Category
Article
ISSN
0883-2889

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✦ Synopsis

This work describes the synthesis and purification of L-6-["Fjfluorodopa synthesized via the reaction of acetyl hypofluorite with a mercury-dopa derivative. The mercurated starting material and the mercury compounds produced in the reaction are efficiently removed by passage of the reaction mixture through a mercaptan modified silica gel. After evaporation the residue was treated with HI, and purified by HPLC to give the pure product in 12% radiochemical yield (decay corrected) and containing < 10 ppb of mercury.

πŸ“œ SIMILAR VOLUMES

Synthesis and separation of 3-O-Methyl-2
Synthesis and separation of 3-O-Methyl-2- and 6-[18F]-fluorodopa
✍ Michael J. Adam; Salma Jivan πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 251 KB

## Abstract 3‐O‐Methyl‐2‐ and 6‐[^18^F]‐fluorodopa were synthesized in 8% radiochemical yield by the direct fluorination of a protected L‐dopa derivative with [^18^F]‐acetyl hypofluorite. The 2‐ and 6‐fluoro isomers were separated and purified by reverse phase HPLC.

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Stereoselective synthesis of 3-o-methyl-6-[18F]fluorodopa via fluorodestannylation
✍ Michael J. Adam; Jianming Lu; Salma Jivan πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 French βš– 233 KB

## Abstract 3‐O‐Methyl‐6‐[^18^F]fluorodopa was synthesized in 20% radiochemical yield in 60 min, with a specific activity of 500 mCi/mmol, by the fluorination of a stannylated dopa precursor with [^18^F]‐acetyl hypofluorite.