Radiofluorination with 18F-labelled acetyl hypofluorite: [18F]L-6-fluorodopa
β Scribed by Raman Chirakal; Gunter Firnau; Joel Couse; E.S. Garnett
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 295 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0020-708X
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π SIMILAR VOLUMES
The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using ['sF]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational
This work describes the synthesis and purification of L-6-["Fjfluorodopa synthesized via the reaction of acetyl hypofluorite with a mercury-dopa derivative. The mercurated starting material and the mercury compounds produced in the reaction are efficiently removed by passage of the reaction mixture