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Synthesis of 18F-labelled VP 16-213 and podophyllotoxin using acetyl hypofluorite

✍ Scribed by Gerard W.M. Visser; Anita T. Bijma; Jessica A.R. Dijksman; Jacobus D.M. Herscheid

Publisher
Elsevier Science
Year
1989
Weight
482 KB
Volume
40
Category
Article
ISSN
0883-2889

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✦ Synopsis

The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using ['sF]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational changes.

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