## Abstract The efficient and rapid nucleophilic exchange of fluorine by fluoride‐^18^F ion in aromatic rings is reported here utilizing rubidium‐^18^F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 10^4^ Ci/mol region are readily achievable. Nucleophilic substitution is shown
✦ LIBER ✦
Radiofluorination of 2-fluoropyridines by isotopic exchange with [18F]fluoride
✍ Scribed by Noeen Malik; Wolfgang Voelter; Hans-Jürgen Machulla; Christoph Solbach
- Book ID
- 106441652
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 502 KB
- Volume
- 287
- Category
- Article
- ISSN
- 1588-2780
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The scope of the nucleophilic aromatic substitution reaction of 2-substituted pyridines with nocarrier-added [ \(\left.{ }^{13} \mathrm{~F}\right]\) fluoride ion (half life : 110 minutes) as its \(\left[{ }^{18} \mathrm{~F}\right] \mathrm{FK}-\mathrm{K}_{222}\) activated complex, has been evaluated