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Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel

✍ Scribed by Su-Hyun Jo; Hee-Kyung Hong; Seon Ha Chong; Han Choe


Book ID
116719309
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
867 KB
Volume
82
Category
Article
ISSN
0024-3205

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Effects of phosphodiesterase (PDE) inhib
✍ Kiyokazu Yunomae; Satoko Ichisaki; Junko Matsuo; Shinichi Nagayama; Koichiro Fuk 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation