𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Common Pharmacophores for Uncharged Human Ether-a-go-go-Related Gene (hERG) Blockers

✍ Scribed by Aronov, Alex M.

Book ID
115465796
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
150 KB
Volume
49
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Effects of phosphodiesterase (PDE) inhib
Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity
✍ Kiyokazu Yunomae; Satoko Ichisaki; Junko Matsuo; Shinichi Nagayama; Koichiro Fuk πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 328 KB

## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation