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Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine

✍ Scribed by Hee-Kyung Hong; Mi-Hyeong Park; Byung Hoon Lee; Su-Hyun Jo

Book ID: 116300015
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 819 KB
Volume: 394
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.03.010

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## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation