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Maprotiline block of the human ether-a-go-go-related gene (HERG) K+channel

✍ Scribed by Su-Hyun Jo; Hee-Kyung Hong; Sung Jun Jung; Seon Ha Chong; Ji-Hyun Yun; Young-Sang Koh; Han Choe

Publisher
Springer
Year
2007
Tongue
English
Weight
916 KB
Volume
30
Category
Article
ISSN
0253-6269

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Effects of phosphodiesterase (PDE) inhib
Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity
✍ Kiyokazu Yunomae; Satoko Ichisaki; Junko Matsuo; Shinichi Nagayama; Koichiro Fuk πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 328 KB

## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation