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Protective action of glycine in cisplatin nephrotoxicity

✍ Scribed by Heyman, Samuel N; Rosen, Seymour; Silva, Patricio; Spokes, Katherine; Egorin, Merrill J; Epstein, Franklin H


Book ID
109881825
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
754 KB
Volume
40
Category
Article
ISSN
0085-2538

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r