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Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity

✍ Scribed by Kazuto Mishima; Anri Baba; Misaki Matsuo; Yoshinori Itoh; Ryozo Oishi


Book ID
113629878
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
907 KB
Volume
40
Category
Article
ISSN
0891-5849

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r