๐”– Bobbio Scriptorium
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Protection of carboxylic acids as methylthiomethyl esters

โœ Scribed by L.G. Wade Jr.; John H. Gerdes; Ronald P. Wirth


Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
133 KB
Volume
19
Category
Article
ISSN
0040-4039

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Methylthiomethyl (KIM) ethers have recently been found to serve as protecting groups for primary,2 secondary3 and tertiary 334 alcohols. It is our belief that phenolic MTM ethers, by virtue of their facile formation and hydrolysis as well as their resistance to a variety of reagents and conditions,

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sunsaary : The carboxamidomethyl esters (CAM esters) are proposed for carboxyl protection in peptide synthesis. Amino acid CAM ester derivatives were easily prepared and showed good stability in the deblocking conditions of other convaon protecting groups used in peptide synthesis. The CAn esters we

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The use of 9-fluorenylmethyl esters for the protection of carboxyl groups is proposed. The advantage of this group is the selective deprotection under mild conditions using secondary amines without racemization. Recently we got knowledge about the use of 9-fluorenylmethyl (Fm) esters for the protec