Protection of tertiary hydroxyl groups as methylthiomethyl ethers
β Scribed by Kiyoyuki Yamada; Kaneyoshi Kato; Hiroshi Nagase; Yoshimasa Hirata
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 147 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Methylthiomethyl (KIM) ethers have recently been found to serve as protecting groups for primary,2 secondary3 and tertiary 334 alcohols. It is our belief that phenolic MTM ethers, by virtue of their facile formation and hydrolysis as well as their resistance to a variety of reagents and conditions,
An extensively used method for the protection of alcohol8 consists of their oonverslon into 2\*-0-tetrahydropyrsnyl-(TIP-)ethers'. Reaotlcn with an exoess of 2,3-dlhydro-4H-pyra3l 111 the presence of trace amounts of (p-toluenesulfonlc) acrd affords the sorresponding THP-ethers In good ylelda. This
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