Carboxamidomethyl esters (CAM esters) as carboxyl protecting groups.
โ Scribed by Jean Martinez; Jeanine Laur; Bertrand Castro
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 165 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
sunsaary : The carboxamidomethyl esters (CAM esters) are proposed for carboxyl protection in peptide synthesis. Amino acid CAM ester derivatives were easily prepared and showed good stability in the deblocking conditions of other convaon protecting groups used in peptide synthesis. The CAn esters were selectively and rapidly hydrolyzed in an alcaline medium.
๐ SIMILAR VOLUMES
The use of 9-fluorenylmethyl esters for the protection of carboxyl groups is proposed. The advantage of this group is the selective deprotection under mild conditions using secondary amines without racemization. Recently we got knowledge about the use of 9-fluorenylmethyl (Fm) esters for the protec
Carboxylic acids were protected as their corresponding 3-butenyl esters. Deprotection was carried out via ozonolysis and P-elimination of the resultant 3acyloxypropanal.
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