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9-fluorenylmethyl esters as carboxyl protecting group

✍ Scribed by Horst Kessler; Rainer Siegmeier

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 90 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)81385-4

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✦ Synopsis

The use of 9-fluorenylmethyl esters for the protection of carboxyl groups is proposed. The advantage of this group is the selective deprotection under mild conditions using secondary amines without racemization.

Recently we got knowledge about the use of 9-fluorenylmethyl (Fm) esters for the protection of carboxyl groups'. This leads us to publish our own results in this field2 which differ in the preparation procedure of the Fm ester, whereas the cleavage conditions are similar to those reported by Bodanszky'.

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