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Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats

✍ Scribed by Kunihiko Sueishi; Kazuto Mishima; Kazutaka Makino; Yoshinori Itoh; Kazuhiko Tsuruya; Hideki Hirakata; Ryozo Oishi


Book ID
114015047
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
331 KB
Volume
451
Category
Article
ISSN
0014-2999

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r