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Prophylactic effect of methylprednisolone against cisplatin-induced nephrotoxicity in rats

✍ Scribed by YASUHIRO, K; JIRO, U; TOYOFUMI, U; TETSUO, Y; JOICHI, K

Book ID
123095664
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
297 KB
Volume
66
Category
Article
ISSN
0378-4274

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Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r