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The Protective Effect of Methylprednisolone against Cisplatin-Induced Nephrotoxicity in Patients with Urothelial Tumors

✍ Scribed by Jiro Uozumi; Yasuhiro Koikawa; Tetsuo Yasumasu; Noriaki Tokuda; Joichi Kumazawa


Book ID
108976173
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
415 KB
Volume
3
Category
Article
ISSN
0919-8172

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✍ Helmut BrΓ€unlich; Dorothea Appenroth; Christian Fleck πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 159 KB πŸ‘ 2 views

Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r