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Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma

โœ Scribed by Eiwa Ishida; Mitsutoshi Nakamura; Miwa Ikuta; Keiji Shimada; Syuichi Matsuyoshi; Tadaaki Kirita; Noboru Konishi

Book ID
113832539
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
159 KB
Volume
41
Category
Article
ISSN
1368-8375

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The INK4a/ARF locus encodes two different proteins, p16 INK4a and p14 ARF , which are crucial for two tumor suppressor pathways. We found that p14 ARF mRNA expression was suppressed in 13 of 37 cases, among which 9 cases showed the inactivation of both of p14 ARF and p16 INK4a , and 4 cases showed t