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Inactivation of the p14ARF, p15INK4B and p16INK4A genes is a frequent event in human oral squamous cell carcinomas

✍ Scribed by Satoru Shintani; Yuuji Nakahara; Mariko Mihara; Yoshiya Ueyama; Tomohiro Matsumura


Book ID
114393753
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
656 KB
Volume
37
Category
Article
ISSN
1368-8375

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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote