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Aberrant methylation of p14ARF, p15INK4b and p16INK4a genes and location of the primary site in pulmonary squamous cell carcinoma

โœ Scribed by Osamu Furonaka; Yukio Takeshima; Hirokazu Awaya; Hajime Ishida; Nobuoki Kohno; Kouki Inai


Book ID
115175351
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
226 KB
Volume
54
Category
Article
ISSN
1320-5463

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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote