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Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma

โœ Scribed by Kenichi Fukai; Osamu Yokosuka; Fumio Imazeki; Motohisa Tada; Rintaro Mikata; Masaru Miyazaki; Takenori Ochiai; Hiromitsu Saisho

Book ID
111237421
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
176 KB
Volume
25
Category
Article
ISSN
0106-9543

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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote