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p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines

✍ Scribed by Laura Borgonovo Brandter; Mats Heyman; Omid Rasool; Yie Liu; Dan Grandér; Stefan Einhorn

Book ID
114792100
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
469 KB
Volume
56
Category
Article
ISSN
0902-4441

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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote