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Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer

✍ Scribed by Mark W.A. Norrie; Nicholas J. Hawkins; Alison V. Todd; Alan P. Meagher; Terence W. O'Connor; Robyn L. Ward

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
141 KB
Volume
84
Category
Article
ISSN
0022-4790

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The p16(INK4a) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including gastric cancers. However, p16(INK4a) promoter hypermethylation in the surrounding non-tumorous tissues of gastric cancers has not been studied in detail. We therefore examined 46