𝔖 Bobbio Scriptorium
✦   LIBER   ✦

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

✍ Scribed by Krimpenfort, Paul; IJpenberg, Annemieke; Song, Ji-Ying; van der Valk, Martin; Nawijn, Martijn; Zevenhoven, John; Berns, Anton

Book ID
109896883
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
984 KB
Volume
448
Category
Article
ISSN
0028-0836

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Alterations of p16INK4A and p15INK4B gen
Alterations of p16INK4A and p15INK4B genes in gastric carcinomas
✍ Young Y. Lee; Shin H. Kang; Jin Y. Seo; Chul W. Jung; Kuhn U. Lee; Kuk J. Choe; πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 199 KB πŸ‘ 1 views

## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote

Homozygous deletion of the p16INK4a and
Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma
✍ Wagner; Wagner; Briedigkeit; Goos πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 453 KB

Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations