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p16INK4A promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner

✍ Scribed by Pei-Fen Su; Wei-Li Huang; Ho-Tai Wu; Cheng-Hsien Wu; Tsung-Yun Liu; Shou-Yen Kao

Book ID
113833390
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
296 KB
Volume
46
Category
Article
ISSN
1368-8375

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## Abstract Inactivation of the __p16^INK4A^__ (__CDKN2A)__ gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. De