Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma

✍ Scribed by Tomoko Kohno; Yasuaki Yamada; Masayuki Tawara; Yumi Takasaki; Shimeru Kamihira; Masao Tomonaga; Toshifumi Matsuyama

• Book ID: 104040339
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 415 KB
• Volume: 31
• Category: Article
• ISSN: 0145-2126
• DOI: 10.1016/j.leukres.2006.12.007

✦ Synopsis

The INK4a/ARF locus encodes two different proteins, p16 INK4a and p14 ARF , which are crucial for two tumor suppressor pathways. We found that p14 ARF mRNA expression was suppressed in 13 of 37 cases, among which 9 cases showed the inactivation of both of p14 ARF and p16 INK4a , and 4 cases showed the inactivation of p14 ARF alone. The inactivation of p14 ARF and the mutation of p53 are mutually exclusive. The patients with the p14 ARF inactivation had shorter survival, similar to that of patients with the p53 mutation. These results indicate that the inactivation of p14 ARF plays a key role in the progression of ATLL.