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Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms

โœ Scribed by Michael G House; James G Herman; Ming Zhou Guo; Craig M Hooker; Richard D Schulick; John L Cameron; Ralph H Hruban; Anirban Maitra; Charles J Yeo


Book ID
119482276
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
280 KB
Volume
134
Category
Article
ISSN
0039-6060

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i