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Preparation of methadone and some congeners labeled with tritium in the aromatic rings

✍ Scribed by J. A. Kepler; C. M. Sparacino; C. R. Howe; R. D. Austin

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
416 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[diphenyl‐2,2′‐^3^H~2~]Methadone with specific activity of 8‐30 Ci/mmol was prepared by reductive dehalogenation of 6‐dimethylamino‐4, 4‐bis(2‐chlorophenyl)‐3‐heptanone with carrier‐free tritium gas. The labeled congeners (−)‐α‐acetylmethadol, (−)‐α‐acetyl‐N‐normethadol, and (−)‐α‐acetyl‐N,N‐dinormethadol were prepared from (+)‐[diphenyl‐2,2′‐^3^H~2~]methadone.

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