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The preparation of tritium labeled methadone and its metabolites

✍ Scribed by Herbert H. Seltzman; Steven D. Wyrick; Colin G. Pitt

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
430 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis and catalytic tritium reduction of 1,2‐dehydro analogs of (‐)‐methadol, (‐)‐α‐acetylmethadol, and (‐)‐α‐acetyl‐N‐normethadol afforded the labeled compounds with high specific activity (44‐60 Ci/ mmole). The use of the homogeneous catalyst (ϕ~3~P)~3~RhCl resulted in specific introduction of tritium without scrambling. (+)‐Methadone‐1‐^3^H (25 Ci/mmole) was obtained by oxidation of (‐)‐methadol‐1,2‐^3^H~2~ followed by sodium hydroxide exchange of the 2‐^3^H.

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