Preparation of GDP-d-mannose specifically labeled with tritium in the d-mannosyl moiety

Preparation of methadone and some congen

Preparation of methadone and some congeners labeled with tritium in the aromatic rings

✍ J. A. Kepler; C. M. Sparacino; C. R. Howe; R. D. Austin 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 416 KB

## Abstract [diphenyl‐2,2′‐^3^H~2~]Methadone with specific activity of 8‐30 Ci/mmol was prepared by reductive dehalogenation of 6‐dimethylamino‐4, 4‐bis(2‐chlorophenyl)‐3‐heptanone with carrier‐free tritium gas. The labeled congeners (−)‐α‐acetylmethadol, (−)‐α‐acetyl‐N‐normethadol, and (−)‐α‐acety