## Abstract The synthesis of ^3^H and ^14^C labeled __d__‐2‐ethyl‐2‐phenyl‐4‐(2‐piperidyl)‐1, 3‐dioxolane hydrochloride (Va and Vb respectively) is described. The optically pure α(‐)‐2‐(2‐piperidyl)ethane‐1,2‐diol hydrochloride (II), obtained by hydrolyzing α (+)‐2,2‐diphenyl‐4‐(2‐piperidyl)‐1,3‐di
Preparation of carbon-14 labeled 2-phenyl-3-[p-(2-diethylaminoethoxy) phenyl]-6-methoxyindene hydrochloride
✍ Scribed by Richard C. Thomas; Paul E. Marlatt
- Book ID
- 102370911
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 220 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
2‐Phenyl‐3‐[p‐(2‐diethylaminoethoxy)phenyl]‐6‐methoxyindene‐3^14^C hydrochloride was prepared from phenylacetic acid‐1‐^14^C in a four step sequence of reactions. The final product was obtained in 12.5% yield at a specific activity of 0.79 mCi per mM.
📜 SIMILAR VOLUMES
%Methyl -6-[3-( t r i f 1 uoromethyl ) phenyl 1-1,2,4-triazolo[4,3-b] p y r i d a z i n e ($), c u r r e n t l y being evaluated as a p o t e n t i a l anxiol y t i c agent was synthesized, l a b e l e d w i t h carbon-14 i n the 3p o s i t i o n o f t h e t r i a z o l o nucleus. i n 67% radiochemi
## Abstract Carbon‐13 and carbon‐14 labeled forms of the title compound have been prepared from the correspondingly labeled forms of 8‐chloro‐1‐methyl‐6‐phenyl‐4H‐__s__‐triazolo[4,3‐a][1,4]benzodiazepine (__3__)Alprazolam is the generic USAN name for this compound. . A modified and more convenient
1 ,l -Oiphenyl-2-methyl-3-aminopropanol-1-"+C was prepared i n a five-step sequence o f reactions from "+C02 and resolved I n t o i t s d and 2 isomers i n an overall y i e l d o f 9.5% based on carbon-14. 1 ,l-Diphenyl-2-methyl-3-aminopropanol-3-~H was prepared by reduction o f an intermediate w l