Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol
✦ LIBER ✦
Preparation of an Autolysis-Resistant Interleukin-1β Converting Enzyme Mutant
✍ Scribed by Dang, Luan C.; Talanian, Robert V.; Banach, David; Hackett, Maria C.; Gilmore, John L.; Hays, Sheryl J.; Mankovich, John A.; Brady, Kenneth D.
- Book ID
- 126929140
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 512 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2960
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Interleukin-1b converting enzyme (ICE) is the first enzyme of a new family of cysteine endoproteinases to be isolated and characterized. An overview of the structure and activity of ICE is outlined together with highlights of salient features common to members of each of the family members.
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