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Induction of interleukin-1β converting enzyme by lipopolysaccharide in mouse microglia

✍ Scribed by Kim, Sung-Wan; Berk, Lesley; Kulkarni, Jayashri; Dodd, Seetal; de Castella, Anthony; Fitzgerald, Paul B; Amminger, G. Paul; Berk, Michael

Book ID
124135660
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
176 KB
Volume
15
Category
Article
ISSN
0197-4580

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Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol