✦ LIBER ✦

Characterization of mice deficient in interleukin-1β converting enzyme

✍ Scribed by Ping Li; Hamish Allen; Subhashis Banerjee; Tara Seshadri

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 66 KB
Volume: 64
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(199701)64:1<27::aid-jcb5>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technology. ICE-deficient mice developed normally, appeared healthy, and were fertile. Peritoneal macrophages from ICE-deficient mice underwent apoptosis normally upon ATP treatment. Thymocytes from young ICE-deficient mice also underwent apoptosis when triggered by dexamethasone, gamma irradiation, or aging. ICE-deficient mice had a major defect in the production of mature IL-1b and had impaired IL-1a production on LPS stimulation in vitro and in vivo. ICE-deficient mice were resistant to LPS-induced endotoxic shock.

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