The interleukin-1β converting enzyme family of cysteine proteases
✍ Scribed by Douglas K. Miller; Joseph Myerson; Joseph W. Becker
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 533 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Interleukin-1b converting enzyme (ICE) is the first enzyme of a new family of cysteine endoproteinases to be isolated and characterized. An overview of the structure and activity of ICE is outlined together with highlights of salient features common to members of each of the family members.
📜 SIMILAR VOLUMES
Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol
Objective. To study the expression and production of interleukin-1-converting enzyme (ICE) in human normal and osteoarthritic (OA) cartilage and synovium, quantitate the level of ICE in OA chondrocytes, and examine the relationship between the topographic distribution of ICE, interleukin-1 (IL-1)
N-Acyl aspartic acid ketones (3a-3n) were prepared from the corresponding bromomethyl ketone. The inhibition of interleukin-lJ3 converting enzyme (ICE) by these single amino acid ketones is reported. The best compound had Ki of 3.5 I~M versus ICE. Peptidyl aldehydes and ketones have been demonstrat