Interleukin-1β-converting enzyme and related proteases as potential targets in inflammation and apoptosis

Suppression of intracellular resistance

Suppression of intracellular resistance factors by adriamycin augments heat-induced apoptosis via interleukin-1β-converting enzyme activation in pancreatic carcinoma cells

✍ Daisuke Kobayashi; Naoki Watanabe; Hiroyoshi Sasaki; Tetsuro Okamoto; Naoki Tsuj 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 79 KB 👁 2 views

Combination of heat and various anticancer drugs can exert a synergistic antitumor effect in vitro and in vivo, though the mechanism is not clear. We have previously shown that endogenous tumor necrosis factor (enTNF) acts as an intracellular resistance factor to inhibit the cytotoxic effect of heat