Cloning, Tissue Expression and Regulation of Rat Interleukin 1β Converting Enzyme
✍ Scribed by Karen M. Keane; David A. Giegel; William J. Lipinski; Michael J. Callahan; Brenda D. Shivers
- Book ID
- 115595842
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 404 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1043-4666
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Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol
Interleukin-1b converting enzyme (ICE) is the first enzyme of a new family of cysteine endoproteinases to be isolated and characterized. An overview of the structure and activity of ICE is outlined together with highlights of salient features common to members of each of the family members.
Objective. To study the expression and production of interleukin-1-converting enzyme (ICE) in human normal and osteoarthritic (OA) cartilage and synovium, quantitate the level of ICE in OA chondrocytes, and examine the relationship between the topographic distribution of ICE, interleukin-1 (IL-1)