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Preparation of 3H- and 14C-labelled contraceptive steroids

✍ Scribed by Kenyu Shibata; Yoshio Osawa; Avery A. Sandberg

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
236 KB
Volume
11
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^3^H‐ and ^14^C‐Labelled ethynodiol diacetate, chlormadinone acetate, and medroxyprogesterone acetate with one label at the steroid nucleus and the other at the acetoxy group were prepared for use in studies of regio‐ and stereospecificity of metabolic hydrolysis of the steroid contraceptives. Steroidal secondary, tertiary, equatorial, and axial acetates were labelled under selective conditions using acetic anhydride.

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