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Preparation of [125I]-3H2-iopiperidol-A by exchange radioiodination

✍ Scribed by Marc Ogan; Frank Tomasella; Jan-I Tu

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
325 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Preparation of radiolabeled [^125^I]‐N,N′‐bis(2,3‐dihydroxypropyl)‐5‐(3‐hydroxy‐2‐oxo‐1‐piperidinyl)‐2,4,6‐ triiodo‐1,3‐benzenedicarboxamide, ([^125^I]‐3H2‐iopiperidol‐A), a nonionic radiographic contrast agent, was achieved by HAuCl~4~ mediated exchange radioiodination. [^125^I]‐Iopiperidol‐A was isolated by reversed‐ phase HPLC in 83% radiochemical yield. The radiochemical purity of isolated [^125^I]‐3H2‐iopiperidol‐A was 98.7% and the specific activity was 6.6 mCi/μmol. The role of HAuCl~4~ in facilitating exchange radioiodination of 3H2‐iopiperidol‐A, however, appears to be a complex process not limited to the production of electrophilic iodine ion.

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