The pyridinyl imidazole cytokine-suppressing anti-inflammatory drug (CSAID"), SB 206718 (1) was required in 1251-labeled form for photoaffinity ligand studies. The target compound (SB 206718-[1251], [1\*5I]l) was obtained via conversion of the highly functionalized 1 to a tributylstannyl derivative.
Preparation of a 125I labelled [1,3H]imidazole: 2-n-butyl-4(5)-125I-iodo-5(4)-hydroxymethylene imidazole
โ Scribed by Philippe R. Bovy; Richard L. Simmons
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 176 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
1251 Amiodarone was prepared by iodination of 1 2SI 251 amiodarone was obtained 2-n butyl 4-hydroxy 3-benzoyl benzofuran with Na in alkaline medium. By amination with N8N-diethyl 2-amino 1 -chloroethane, with 30 % yield and a specific activity of about 1 Ci/mmOl.
## Abstract The radiolabelling of an iodinated analog of mazindol, 5โ(4โ[^125^I]โiodophenyl)โ2,3โdihydroโ5โhydroxyโ5Hโimidazo[2,1โa]isoindole, was performed in order to develop a potential tool for SPECT exploration of the presynaptic dopamine transporter in the human brain. Radiosynthesis was perf
## Abstract The synthesis of the first high specific activity {^125^I} labelled selective H~3~ antagonist, Iodophenpropitโ i.e., Sโ[3โ(4(5)โimidazolyl)propyl],Nโ[2โ(4โ{^125^I}โiodophenyl)ethyl]isothiourea sulfate is reported. The radiolabelled compound was prepared by Cu(I)assisted nucleophilic no
## Abstract We describe the preparation of ^125^I labelling with a higher specific radioactivity of N(1โethyl โ2โpyrrolidylโmethyl)2โ methoxy โ5โethyl sulfonyl benzamide, a potent biological analogue for sulpiride. The incorporation of iodine in the molecule was achieved by the substitution of arom