✦ LIBER ✦

Synthesis of 2-n butyl 3-(3,5-125diiodo 4-(N, N-diethylamino 2-ethoxybenzoyl)) benzofuran hydrochloride (125I amiodarone)

✍ Scribed by R. Sion

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 210 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220807

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✦ Synopsis

1251 Amiodarone was prepared by iodination of 1 2SI

251 amiodarone was obtained 2-n butyl 4-hydroxy 3-benzoyl benzofuran with Na in alkaline medium. By amination with N8N-diethyl 2-amino 1 -chloroethane, with 30 % yield and a specific activity of about 1 Ci/mmOl.

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