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Synthesis of N-[4-(2-dimethylaminoethoxy) benzyl-α-14C]-3,4,5-trimethoxybenzamide hydrochloride and N-[4-(2- methylaminoethoxy)benzyl-α-14C]-3, 4-diethoxybenzamide hydrochloride

✍ Scribed by R. L. Wineholt; J. D. Johnson; P. J. Heck; H. H. Kaegi

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
394 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

The anti-emetic compounds N-[4-(2-dimethylaminoethoxy

j benzyla-f4C]-3,4,5-trimethoxybenzamide hydrochloride (10) and N44-(2-methylaminoethoxy)benzyl-a-f~C]-3,4-diethoxybenzamide hydrochloride ( 1 1 j were prepared. The synthesis of 10 in four steps provided the purijied material in 29 % yield from carbon dioxide. The same series of reactions was used to prepare N-[4-(2-benzylmethylaminoethoxy) benzyl-a-14CC]-3,4-diethoxybenzamide (9), which after an additional debenzylation step furnished 1 1 in 56 % yield based on carbon dioxide.

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