✦ LIBER ✦

Synthesis of 4-[2-(4-Azidophenyl)-5-(3-iodo-125I-phenyl)-1H-imidazol-4-yl]pyridine (SB 206718-[125I]), a pyridinyl imidazole cytokine inhibitor

✍ Scribed by Keith T. Garnes; Scott W. Landvatter; Timothy F. Gallagher

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 345 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199607)38:7<637::aid-jlcr871>3.0.co;2-t

No coin nor oath required. For personal study only.

✦ Synopsis

The pyridinyl imidazole cytokine-suppressing anti-inflammatory drug (CSAID"), SB 206718 (1) was required in 1251-labeled form for photoaffinity ligand studies. The target compound (SB 206718-[1251], [1*5I]l) was obtained via conversion of the highly functionalized 1 to a tributylstannyl derivative. Radioiododestannylation using Na125I in the presence of chloramine-T gave good radiochemical yields of the title compound (42-69%, four radiosyntheses) at high radiochemical purity (>98%) after HPLC purification at specific activities of 1670-1736 Ci/mmol.

📜 SIMILAR VOLUMES

Preparation of a 125I labelled [1,3H]imi

Preparation of a 125I labelled [1,3H]imidazole: 2-n-butyl-4(5)-125I-iodo-5(4)-hydroxymethylene imidazole

✍ Philippe R. Bovy; Richard L. Simmons 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB

Efficient Synthesis of 4-(3-Fluoro-5-{ [

Efficient Synthesis of 4-(3-Fluoro-5-{ [4-(2-methyl-1H-imidazol-1-yl)benzyl] oxy}phenyl)tetrahydro-2H-pyran-4-carboxamide, a Novel 5-Lipoxygenase Inhibitor.

✍ Takashi Mano; Rodney W. Stevens; Kazunari Nakao; Yoshiyuki Okumura; Kiyoshi Kawa 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views