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Preparation of pteroylglutamic acid-3′,5′-2H2 by acid catalyzed exchange with deuterium oxide

✍ Scribed by D. L. Hachey; L. Palladino; J. A. Blair; I. H. Rosenberg; P. D. Klein

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
295 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Pteroylglutamic acid was labeled with deuterium by trifluoroacetic acid-catalyzed exchange with deuterium oxide.

The product, pteroylglutamic acid-3',5'-H2, was selectively labeled with deuterium in the 4-aminobenzoyl portion of the molecule; there was no evidence for isotope incorporation at C or C of the pteridine ring or at the glutamate residue. Isotope composition of the pteroylglutamates was determined by chemical ionization mass spectrometry following a base-catalyzed, oxidative cleavage to either 4-aminobenzoic acid or 4-aminobenzoyl-2 7 9 glutamic acid.

contained 1% Ho, 9% H1, and 90% H isotopic species.

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