## Abstract trans‐Ionylideneacetaldehyde‐1‐^3^H (3) was obtained by reduction of unlabeled aldehyde 1 with lithium borotritide, followed by reoxidation of the tritio alcohol 2. Condensation of aldehyde 3 with diethyl 3‐cyano‐2‐methylprop‐2‐enylphosphonate (7) afforded retinonitrile‐11‐^3^H (8) whic
Preparation of 11-cis-retinal-11-3H
✍ Scribed by H H. Kaegi; J E Bupp
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 177 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
trans‐Retinal‐11‐^3^H was photolyzed by a fluorescent source to afford a mixture of isomeric retinals, from which 11‐cis‐retinal‐11‐^3^H was isolated by HPLC.
📜 SIMILAR VOLUMES
## SYNTHESIS OF 13-e-(ll-3H)-RETINOIC ACID The b i o l o g i c a l a c t i v i t y of 1 3 -e -r e t i n o i c a c i d i n p r e v e n t i o n of e p i t h e l i a l cancer i n animals h a s r e c e n t l y been demonstrated [l]. I n c o n n e c t i o n w i t h a m e t a b o l i c s t u d i e s pro
## Abstract __Trans__‐ionylidineacetaldehyde‐1‐^3^H (**3**) was obtained by reduction of unlabeled aldehyde (**1**) with lithium borotritide, followed by reoxidation of the tritio alcohol (**2**). Condensation of aldehyde (**3**) with triethyl 3‐methyl‐4‐phosphonocrotonate (**7**), followed by sapo
## Abstract All‐__trans__‐Retinoic acid [11,12‐^3^H(N)] was photochemically isomerized using a fluorescent source to afford a mixture of isomeric retinoic acids, from which 9‐__cis__‐retinoic acid[11,12‐^3^H(N)] was isolated by reversed‐phase HPLC. The identity of 9‐__cis__‐retinoic acid [11, 12‐^3
## Abstract A selective total synthesis of [11,12‐^3^H]‐9‐__cis__‐retinoic acid 1 at a specific activity of 46 Ci/mmole is described. The alkyne 4, efficiently prepared in two steps from readily available starting materials, was partially reduced to 9,11‐di‐__cis__‐retinoic acid 3 with both deuteri
Starting with tritiated all-trans-retinyl acetate the preparation of tritiated retinol is described.