## Abstract trans‐Ionylideneacetaldehyde‐1‐^3^H (3) was obtained by reduction of unlabeled aldehyde 1 with lithium borotritide, followed by reoxidation of the tritio alcohol 2. Condensation of aldehyde 3 with diethyl 3‐cyano‐2‐methylprop‐2‐enylphosphonate (7) afforded retinonitrile‐11‐^3^H (8) whic
Preparation of all-trans-11-3H-retinol from its acetate
✍ Scribed by H. H. Kaegi; J. E. Bupp
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 108 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Starting with tritiated all-trans-retinyl acetate the preparation of tritiated retinol is described.
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## Abstract __Trans__‐ionylidineacetaldehyde‐1‐^3^H (**3**) was obtained by reduction of unlabeled aldehyde (**1**) with lithium borotritide, followed by reoxidation of the tritio alcohol (**2**). Condensation of aldehyde (**3**) with triethyl 3‐methyl‐4‐phosphonocrotonate (**7**), followed by sapo
## Abstract Lithium borotritide reduction of α‐ionylidene‐acetaldehyde (5) followed by manganese dioxide oxidation provided the tritiated aldehyde (9) which retainad over 95% of the label. On treatment with the ylide derived from ethyl 4‐chloro‐3‐methylcrotonate, ethyl α‐retinoate‐11‐^3^H (14) was
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