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Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues

โœ Scribed by Andrews, K. T.; Tran, T. N.; Lucke, A. J.; Kahnberg, P.; Le, G. T.; Boyle, G. M.; Gardiner, D. L.; Skinner-Adams, T. S.; Fairlie, D. P.


Book ID
121341237
Publisher
American Society for Microbiology
Year
2008
Tongue
English
Weight
395 KB
Volume
52
Category
Article
ISSN
0066-4804

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## Abstract Various structurally modified analogues of FR235222 (**1**), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core i