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Thiol-Based SAHA Analogues as Potent Histone Deacetylase Inhibitors.

โœ Scribed by Takayoshi Suzuki; Akiyasu Kouketsu; Azusa Matsuura; Arihiro Kohara; Shin-ichi Ninomiya; Kohfuku Kohda; Naoki Miyata


Publisher
John Wiley and Sons
Year
2004
Weight
13 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Various structurally modified analogues of FR235222 (**1**), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core i