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New aryldithiolethione derivatives as potent histone deacetylase inhibitors

โœ Scribed by Valerio Tazzari; Graziella Cappelletti; Manolo Casagrande; Elena Perrino; Luigi Renzi; Piero Del Soldato; Anna Sparatore


Book ID
108072851
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
287 KB
Volume
18
Category
Article
ISSN
0968-0896

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Novel Sulfonamide Derivatives as Inhibit
โœ Paulโ€…W. Finn; Morwena Bandara; Chris Butcher; Angela Finn; Ruth Hollinshead; Nag ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 374 KB

## Abstract Inhibition of the enzyme histone deacetylase (HDAC) is emerging as a novel approach to the treatment of cancer. A series of novel sulfonamide derivatives were synthesized and evaluated for their ability to inhibit human HDAC. Compounds were identified which are potent enzyme inhibitors,